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1

Abnormal development of the sinuatrial venous valve and posterior hindbrain may contribute to late fetal resorption of vitamin A-deficient rat embryos

Jeffrey C. White, Margaret Highland, Margaret Clagett-Dame

Journal:

Birth Defects Research Part A: Clinical and Molecular Teratology

Year:

2000

Language:

english

File:

PDF, 345 KB

english, 2000

2

Appearance of neurons in the developing chick gut

Colin L. Fairman, Margaret Clagett-Dame, Vanda A. Lennon, Miles L. Epstein

Journal:

Developmental Dynamics

Year:

1995

Language:

english

File:

PDF, 2.65 MB

english, 1995

3

Developmental regulation of human truncated nerve growth factor receptor

Dr Peter S. DiStefano, Margaret Clagett-Dame, Diane M. Chelsea, Rebekah Loy

Journal:

Annals of Neurology

Year:

1991

Language:

english

File:

PDF, 739 KB

english, 1991

4

ChemInform Abstract: An Unhydrolyzable Analogue (V) of N-(4-Hydroxyphenyl)retinamide: Synthesis and Preliminary Biological Studies.

Kevin L. Weiss, Galal Alshafie, Jason S. Chapman, Serena M. Mershon, Hussein Abou-Issa, Margaret Clagett-Dame, Robert W. Curley Jr.

Journal:

Year:

2001

File:

PDF, 29 KB

2001

5

Crk-associated substrate (Cas) family member, NEDD9, is regulated in human neuroblastoma cells and in the embryonic hindbrain by all-trans retinoic acid

Ronald A. Merrill, Angela Wai-Man See, Margaret L. Wertheim, Margaret Clagett-Dame

Journal:

Developmental Dynamics

Year:

2004

Language:

english

File:

PDF, 1.59 MB

english, 2004

6

Calmin expression in embryos and the adult brain, and its regulation by all-trans retinoic acid

Mark A. Marzinke, Elizabeth M. Henderson, Katherine S. Yang, Angela Wai-Man See, Danielle C. Knutson, Margaret Clagett-Dame

Journal:

Developmental Dynamics

Year:

2010

Language:

english

File:

PDF, 559 KB

english, 2010

7

The vitamin D analogue 2MD increases bone turnover but not BMD in postmenopausal women with osteopenia: Results of a 1-year phase 2 double-blind, placebo-controlled, randomized clinical trial

Hector F DeLuca, Wendy Bedale, Neil Binkley, J Chris Gallagher, Michael Bolognese, Munro Peacock, John Aloia, Margaret Clagett-Dame, Lori Plum

Journal:

Journal of Bone and Mineral Research

Year:

2011

Language:

english

File:

PDF, 215 KB

english, 2011

8

Role of all-trans retinoic acid in neurite outgrowth and axonal elongation

Margaret Clagett-Dame, Elizabeth M. McNeill, Parag D. Muley

Journal:

Developmental Neurobiology

Year:

2006

Language:

english

File:

PDF, 440 KB

english, 2006

9

Synthesis and preliminary chemotherapeutic evaluation of the fully C-linked glucuronide of N-(4-hydroxyphenyl)retinamide

Joel R. Walker, Galal Alshafie, Nirca Nieves, Jamie Ahrens, Margaret Clagett-Dame, Hussein Abou-Issa, Robert W. Curley Jr.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 246 KB

english, 2006

10

Synthesis and biological properties of 2-methylene-19-nor-25-dehydro-1α-hydroxyvitamin D3-26,23-lactones—weak agonists

Grazia Chiellini, Pawel Grzywacz, Lori A. Plum, Rafal Barycki, Margaret Clagett-Dame, Hector. F. DeLuca

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 1.03 MB

english, 2008

11

13-Methyl-substituted des-C,D analogs of (20S)-1α,25-dihydroxy-2-methylene-19-norvitamin D3 (2MD): Synthesis and biological evaluation

Katarzyna Plonska-Ocypa, Rafal R. Sicinski, Lori A. Plum, Pawel Grzywacz, Jadwiga Frelek, Margaret Clagett-Dame, Hector F. DeLuca

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 354 KB

english, 2009

12

Removal of the 20-methyl group from 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 (2MD) selectively eliminates bone calcium mobilization activity

Rafal Barycki, Rafal R. Sicinski, Lori A. Plum, Pawel Grzywacz, Margaret Clagett-Dame, Hector F. DeLuca

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 926 KB

english, 2009

13

Solid phase-assisted synthesis and screening of a small library of N-(4-hydroxyphenyl)retinamide (4-HPR) analogs

Serena M. Mershon, Allyson L. Anding, Jason S. Chapman, Margaret Clagett-Dame, Laura A. Stonerock, Robert W. Curley Jr.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 150 KB

english, 2007

14

An unhydrolyzable analogue of N-(4-hydroxyphenyl)retinamide: synthesis and preliminary biological studies

Kevin L Weiss, Galal Alshafie, Jason S Chapman, Serena M Mershon, Hussein Abou-Issa, Margaret Clagett-Dame, Robert W Curley Jr.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 175 KB

english, 2001

15

Synthesis and receptor binding affinity of conformationally restricted retinoic acid analogues

Man Fai Wong, Joyce J Repa, Margaret Clagett-Dame, Robert W Curley Jr.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 292 KB

english, 1997

16

Nav2is necessary for cranial nerve development and blood pressure regulation

Elizabeth M McNeill, Kenneth P Roos, Dieder Moechars, Margaret Clagett-Dame

Journal:

Neural Development

Year:

2010

Language:

english

File:

PDF, 3.00 MB

english, 2010

17

2MD, a new anabolic agent for osteoporosis treatment

Lori A. Plum, Lorraine A. Fitzpatrick, Xiaohong Ma, Neil C. Binkley, Julia B. Zella, Margaret Clagett-Dame, Hector F. DeLuca

Journal:

Osteoporosis International

Year:

2006

Language:

english

File:

PDF, 451 KB

english, 2006

18

10.1038/83792

Mendelsohn, Cathy, Batourina, Ekatherina, Gim, Suzanna, Bello, Natalie, Shy, Michael, Clagett-Dame, Margaret, Srinivas, Shankar, Costantini, Frank

Journal:

Nature Genetics

Year:

2001

Language:

english

File:

PDF, 514 KB

english, 2001

19

A New Vitamin D Analog, 2MD, Restores Trabecular and Cortical Bone Mass and Strength in Ovariectomized Rats With Established Osteopenia

Hua Zhu Ke, Hong Qi, D Todd Crawford, Hollis A Simmons, Gang Xu, Mei Li, Lori Plum, Margaret Clagett-Dame, Hector F DeLuca, David D Thompson, Thomas A Brown

Journal:

Journal of Bone and Mineral Research

Year:

2005

Language:

english

File:

PDF, 1.13 MB

english, 2005

20

Effect of 2-Methylene-19-nor-(20S)-1α-Hydroxy-Bishomopregnacalciferol (2MbisP), an Analog of Vitamin D, on Secondary Hyperparathyroidism

Eduardo Slatopolsky, Jane L Finch, Alex J Brown, Cynthia S Ritter, Masahide Mizobuchi, Lori A Plum, Margaret Clagett-Dame, Rafal R Sicinski, Hector F DeLuca

Journal:

Journal of Bone and Mineral Research

Year:

2007

Language:

english

File:

PDF, 3.09 MB

english, 2007

21

The all-trans retinoic acid (atRA)-regulated gene Calmin (Clmn) regulates cell cycle exit and neurite outgrowth in murine neuroblastoma (Neuro2a) cells

Mark A. Marzinke, Margaret Clagett-Dame

Journal:

Experimental Cell Research

Year:

2012

Language:

english

File:

PDF, 979 KB

english, 2012

22

Astrocytes as a regulated source of retinoic acid for the brain

Kirsty D. Shearer, Yara D. Fragoso, Margaret Clagett-Dame, Peter J. McCaffery

Journal:

Year:

2012

Language:

english

File:

PDF, 2.16 MB

english, 2012

23

Vitamin A Deficiency Results in the Dose-Dependent Acquisition of Anterior Character and Shortening of the Caudal Hindbrain of the Rat Embryo

Jeffrey C. White, Margaret Highland, Mary Kaiser, Margaret Clagett-Dame

Journal:

Developmental Biology

Year:

2000

Language:

english

File:

PDF, 2.13 MB

english, 2000

24

One-Step Immunoaffinity Purification of Recombinant Human Retinoic Acid Receptor γ

Joyce J. Repa, Jessica A. Berg, Mary E. Kaiser, Kristine K. Hanson, Stephen A. Strugnell, Margaret Clagett-Dame

Journal:

Protein Expression and Purification

Year:

1997

Language:

english

File:

PDF, 2.84 MB

english, 1997

25

N-linked oligosaccharides are responsible for rat striatal dopamine D2 receptor heterogeneity

Margaret Clagett-Dame, Jeffrey F. McKelvy

Journal:

Archives of Biochemistry and Biophysics

Year:

1989

Language:

english

File:

PDF, 3.04 MB

english, 1989

26

Preparation of an affinity chromatography matrix for the selective purification of the dopamine D2 receptor from bovine striatal membranes

Margaret Clagett-Dame, Robert Schoenleber, Christine Chung, Jeffrey F. McKelvy

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1989

Language:

english

File:

PDF, 996 KB

english, 1989

27

Isolation and characterization of unsaturated fatty acids as natural ligands for the retinoid-X receptor

Jonathan T Goldstein, Agnieszka Dobrzyn, Margaret Clagett-Dame, J.Wesley Pike, Hector F DeLuca

Journal:

Archives of Biochemistry and Biophysics

Year:

2003

Language:

english

File:

PDF, 323 KB

english, 2003

28

Hydrolysis of 4-HPR to atRA occurs in vivo but is not required for retinamide-induced apoptosis

Jason S Chapman, Kevin L Weiss, Robert W Curley Jr., Margaret A Highland, Margaret Clagett-Dame

Journal:

Archives of Biochemistry and Biophysics

Year:

2003

Language:

english

File:

PDF, 284 KB

english, 2003

29

Methyl substitution of the 25-hydroxy group on 2-methylene-19-nor-1α,25-dihydroxyvitamin D3 (2MD) reduces potency but allows bone selectivity

Pawel Grzywacz, Lori A. Plum, Rafal R. Sicinski, Margaret Clagett-Dame, Hector F. DeLuca

Journal:

Archives of Biochemistry and Biophysics

Year:

2007

Language:

english

File:

PDF, 626 KB

english, 2007

30

2-Methylene-19-nor-1α-hydroxyvitamin D3 analogs inhibit adipocyte differentiation and PPARγ2 gene transcription

Brian Thomson, Jamie M. Ahrens, James M. Ntambi, Hector F. DeLuca, Margaret Clagett-Dame

Journal:

Archives of Biochemistry and Biophysics

Year:

2007

Language:

english

File:

PDF, 1.56 MB

english, 2007

31

Responsiveness of human retinoblastoma and neuroblastoma models to a non-calcemic 19-nor Vitamin D analog

Daniel M. Albert, Lori A. Plum, William Yang, Marcus Marcet, Mary J. Lindstrom, Margaret Clagett-Dame, Hector F. DeLuca

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2005

Language:

english

File:

PDF, 223 KB

english, 2005

32

Selective analogs of 1α,25-dihydroxyvitamin D3 for the study of specific functions of Vitamin D

Hector F. DeLuca, Lori A. Plum, Margaret Clagett-Dame

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2007

Language:

english

File:

PDF, 380 KB

english, 2007

33

Synthesis and biological activities of vitamin D-like inhibitors of CYP24 hydroxylase

Grazia Chiellini, Simona Rapposelli, Jinge Zhu, Ilaria Massarelli, Marilena Saraceno, Anna Maria Bianucci, Lori A. Plum, Margaret Clagett-Dame, Hector F. DeLuca

Journal:

Year:

2012

Language:

english

File:

PDF, 1.36 MB

english, 2012

34

Retinoic acid influences the development of the inferior olivary nucleus in the rodent

Miyuki Yamamoto, Masahiro Fujinuma, Shinji Hirano, Yoshika Hayakawa, Margaret Clagett-Dame, Jinghua Zhang, Peter McCaffery

Journal:

Developmental Biology

Year:

2005

Language:

english

File:

PDF, 2.02 MB

english, 2005

35

A nutritional model of late embryonic vitamin A deficiency produces defects in organogenesis at a high penetrance and reveals new roles for the vitamin in skeletal development

Angela Wai-Man See, Mary E. Kaiser, Jeffrey C. White, Margaret Clagett-Dame

Journal:

Developmental Biology

Year:

2008

Language:

english

File:

PDF, 4.92 MB

english, 2008

36

The temporal requirement for vitamin A in the developing eye: Mechanism of action in optic fissure closure and new roles for the vitamin in regulating cell proliferation and adhesion in the embryonic retina

Angela Wai-Man See, Margaret Clagett-Dame

Journal:

Developmental Biology

Year:

2009

Language:

english

File:

PDF, 2.54 MB

english, 2009

37

Nav2 hypomorphic mutant mice are ataxic and exhibit abnormalities in cerebellar development

Elizabeth M. McNeill, Mariana Klöckner-Bormann, Elizabeth C. Roesler, Lynn E. Talton, Dieder Moechars, Margaret Clagett-Dame

Journal:

Developmental Biology

Year:

2011

Language:

english

File:

PDF, 3.41 MB

english, 2011

38

Vitamin A deficiency in the late gastrula stage rat embryo results in a one to two vertebral anteriorization that extends throughout the axial skeleton

Mary E Kaiser, Ronald A Merrill, Adam C Stein, Edith Breburda, Margaret Clagett-Dame

Journal:

Developmental Biology

Year:

2003

Language:

english

File:

PDF, 844 KB

english, 2003

39

Teratogen-Induced, Dietary and Genetic Models of Congenital Diaphragmatic Hernia Share a Common Mechanism of Pathogenesis

Robin D. Clugston, Jürgen Klattig, Chistoph Englert, Margaret Clagett-Dame, Jelena Martinovic, Alexandra Benachi, John J. Greer

Journal:

The American Journal of Pathology

Year:

2006

Language:

english

File:

PDF, 1.02 MB

english, 2006

40

T HE R OLE OF V ITAMIN A IN M AMMALIAN R EPRODUCTION AND E MBRYONIC D EVELOPMENT

Clagett-Dame, Margaret, DeLuca, Hector F.

Journal:

Annual Review of Nutrition

Year:

2002

Language:

english

File:

PDF, 496 KB

english, 2002

41

Vitamin A in Reproduction and Development

Clagett-Dame, Margaret, Knutson, Danielle

Journal:

Year:

2011

Language:

english

File:

PDF, 819 KB

english, 2011

42

New 2-Alkylidene 1α,25-Dihydroxy-19-norvitamin D 3 Analogues of High Intestinal Activity: Synthesis and Biological Evaluation of 2-(3‘-Alkoxypropylidene) and 2-(3‘-Hydroxypropylidene) Derivatives

Glebocka, Agnieszka, Sicinski, Rafal R., Plum, Lori A., Clagett-Dame, Margaret, DeLuca, Hector F.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 409 KB

english, 2006

43

4-Hydroxybenzyl Modification of the Highly Teratogenic Retinoid, 4-[(1 E )-2-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)-1-propen-1-yl]benzoic Acid (TTNPB), Yields a Compound That Induces Apoptosis in Breast Cancer Cells and Shows Reduced Teratogenicity

Anding, Allyson L., Nieves, Nirca J., Abzianidze, Victoria V., Collins, Michael D., Curley, Robert W., Clagett-Dame, Margaret

Journal:

Chemical Research in Toxicology

Year:

2011

Language:

english

File:

PDF, 2.04 MB

english, 2011

44

14-3-3ε and NAV2 interact to regulate neurite outgrowth and axon elongation

Marzinke, Mark A., Mavencamp, Terri, Duratinsky, Joseph, Clagett-Dame, Margaret

Journal:

Archives of Biochemistry and Biophysics

Year:

2013

Language:

english

File:

PDF, 1.73 MB

english, 2013

45

26-Desmethyl-2-methylene-22-ene-19-nor-1α,25-dihydroxyvitamin D3 compounds selectively active on intestine

Chiellini, Grazia, Grzywacz, Pawel, Plum, Lori A., Clagett-Dame, Margaret, DeLuca, Hector F.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.55 MB

english, 2014

46

The effect of age on muscarinic receptor transcripts in rat brain

Lee, Hwa-Jung, Clagett-Dame, Margaret, Heideman, Warren, Weiler, Molly S.

Journal:

Neuroscience Letters

Year:

1994

Language:

english

File:

PDF, 616 KB

english, 1994

47

26- and 27-Methyl groups of 2-substituted, 19-nor-1α,25-dihydroxylated vitamin D compounds are essential for calcium mobilization in vivo

Grzywacz, Pawel, Plum, Lori A., Clagett-Dame, Margaret, DeLuca, Hector F.

Journal:

Bioorganic Chemistry

Year:

2013

Language:

english

File:

PDF, 1.31 MB

english, 2013

48

Defects in Embryonic Hindbrain Development and Fetal Resorption Resulting from Vitamin A Deficiency in the Rat are Prevented by Feeding Pharmacological Levels of All-trans-Retinoic Acid

Jeffrey C. White, V. Narayanaswamy Shankar, Margaret Highland, Miles L. Epstein, Hector F. DeLuca and Margaret Clagett-Dame

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.94 MB

english, 1998

49

Removal of the 26-Methyl Group from 19-nor-1α,25-Dihydroxyvitamin D 3 Markedly Reduces in Vivo Calcemic Activity without Altering in Vitro VDR Binding, HL-60 Cell Differentiation, and Transcription

Grzywacz, Pawel, Chiellini, Grazia, Plum, Lori A., Clagett-Dame, Margaret, DeLuca, Hector F.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.43 MB

english, 2010

50

A 20 S Combined with a 22 R Configuration Markedly Increases both in Vivo and in Vitro Biological Activity of 1α,25-Dihydroxy-22-methyl-2-methylene-19-norvitamin D 3

Flores, Agnieszka, Sicinski, Rafal R., Grzywacz, Pawel, Thoden, James B., Plum, Lori A., Clagett-Dame, Margaret, DeLuca, Hector F.

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 3.53 MB

english, 2012

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